Doctoral theses
Doctoral theses derived from the Division of Translational Cancer Research (TCR). Click on the title for a direct link to the full electronic copy of the thesis.
Therapeutic potential of miR-379 in prostate cancer
Author: James Cassidy
Main Supervisor: Yvonne Ceder
Co-Supervisor: Daniel Bexell
Opponent: Cecilia Williams
Defense date: January 11th, 2024, 09:00
Defense location: Allvar Auditorium, Medicon Village
Publisher: Division of Translational Cancer Research
Research Portal
Therapeutic strategies for high-risk neuroblastoma
Author: Katarzyna Radke
Main Supervisor: Daniel Bexell
Co-Supervisor: Kristina Aaltonen
Faculty Opponent: Professor Louis Chesler, Institute of Cancer Research, London, UK
Defense date: June 8th, 2023, 09:00
Defense location: Hörsalen (Auditorium), Medicon Village
Publisher: Division of Translational Cancer Research (TCR)
Molecular Markers and Hypoxia in Renal Cell Carcinoma
Author: Roger de Alwis
Main Supervisor: Håkan Axelson
Co-Supervisor: Kristian Pietras and David Lindgren
Faculty Opponent: Associate Professor Alan McIntyre, University of Nottingham, UK
Defense date: May 24th, 2023, 09:00
Defense location: Hörsalen (Auditorium), Medicon Village
Publisher: Division of Translational Cancer Research (TCR)
Cancer and Therapy: A look into stemness and the tumour microenvironment
Author: Carmen Rodriguez-Cupello
Main Supervisor: Kristian Pietras
Co-Supervisor: Anna Blom
Faculty Opponent: Professor Eric O'Neill, University of Oxford
Defense date: June 9th, 2022, 09:00
Defense location: Sharience, the Spark, Medicon Village
Publisher: Division of Translational Cancer Research (TCR)
Mechanisms of TRAIL- and Smac mimetic-induced cell death and phenotypical changes in breast cancer
Author: Victoria Granqvist
Main Supervisor: Christer Larsson
Co-Supervisor: Alexander Pietras
Faculty Opponent: Professor Bengt Hallberg, University of Gothenburg
Defense date: May 24th, 2022, 09:00
Defense location: Sharience, the Spark, Medicon Village
Publisher: Division of Translational Cancer Research (TCR)
Prostate cancer tissue biomarkers
Author: Felicia-Elena Marginean
Main Supervisor: Anders Bjartell
Co-Supervisor: Rebecka Hellsten and Agnieszka Krzyzanowska
Faculty Opponent: Associate professor Arno van Leenders, Rotterdam
Defense date: May 16th, 2022, 09:00
Defense location: Agardhsalen, CRC, Malmö
Publisher: Division of Translational Cancer Research (TCR)
The role of protein kinases in development and disease
Author: Renée Daams
Main Supervisor: Ramin Massoumi
Co-Supervisor: Karin Leandersson and Anette Gjörloff Wingren
Faculty Opponent: Professor Edvard Smith, Karolinska Institute
Defense date: March 24th, 2022, 09:00
Defense location: Sharience, Spark building at Medicon Village, and via Zoom
Publisher: Division of Translational Cancer Research (TCR)
Integrative studies of brain pericytes and their involvement in glioma and COVID-19
Author: Clara Oudenaarden
Main Supervisor: Kristian Pietras
Co-Supervisor: Göran B Jönsson
Faculty Opponent: Dr. Annika Keller, Division of Neurosurgery, University Hospital of Zürich
Defense date: February 11th, 2022, 09:00
Defense location: Sharience, Spark building at Medicon Village, and via Zoom
Publisher: Division of Translational Cancer Research (TCR)
The importance of Cyclophilins and Mps1 in cancer
Author: Sonia Simón Serrano
Main Supervisor: Ramin Massoumi
Co-Supervisor: Magnus J Hansson, Eskil Elmer and Daniel Bexell
Faculty Opponent: Prof. Peter R Galle, Universitätsmedizin der Johannes Gutenberg-Universität Main
Defense date: February 4th, 2022, 09:00
Defense location: GK-salen BMC and via Zoom
Publisher: Division of Translational Cancer Research (TCR)
Deregulation and editing of microRNAs in metastatic prostate cancer
Author: Gjendine Voss
Main Supervisor: Yvonne Ceder
Co-Supervisor: Håkan Axelson and Anders Bjartell
Faculty Opponent: Prof. Guido Jenster, Department of Urology, Erasmus University Medical Center, Rotterdam
Defense date: December 2nd, 2021, 09:00
Defense location: Stora Hörsalen, Medicon Village
Publisher: Division of Translational Cancer Research (TCR)
Stromal and tumor cell responses to hypoxia and treatment within the glioma microenvironment
Author: Vasiliki Pantazopoulou
Main Supervisor: Alexander Pietras
Co-Supervisor: Håkan Axelson
Faculty Opponent: Doc. Margareta Wilhelm, Karolinska Institute, Stockholm
Defense date: October 29th, 2021, 09:00
Defense location: Stora Hörsalen, Medicon Village
Publisher: Division of Translational Cancer Research (TCR)
Mechanisms of therapy resistance in acute lymphoblastic leukemia
Author: Kinjal Shah
Main Supervisor: Kazi Jhulash Uddin
Co-Supervisor: Lars Rönnstrand and Kristian Pietras
Faculty Opponent: Prof. Jean-Baptiste Demoulin, Université Catholique de Louvain, Brussels, Belgium
Defense date: October 28th, 2021, 09:15
Defense location: MV404, E24, via Zoom
Publisher: Division of Translational Cancer Research (TCR)
Role of FLT3 in Acute Myeloid Leukemia: Molecular mechanisms and Therapeutic opportunities
Author: Sausan Moharram
Main Supervisor: Lars Rönnstrand
Co-Supervisor: Kazi Jhulash Uddin and Björn Tore
Faculty Opponent: Prof. Atanasio Pandiella, University of Salamanca, Spain
Defense date: June 9th, 2021, 09:00
Defense location: MV404, E24, via Zoom
Publisher: Division of Translational Cancer Research (TCR)
Preclinical investigation of novel therapies against neuroblastoma
Author: Karin Hansson
Main supervisor: Daniel Bexell
Faculty opponent: Associate professor Fredrik Swartling, Uppsala
Defense date: 4 December, 2020, 09:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Harnessing urinary extracellular vesicles microRNA by acoustic trapping as potential biomarkers for prostate cancer
Author: Anson Ku
Main supervisor: Yvonne Ceder
Faculty opponent: Professor Juan Manuel Falcón Pérez, Derio Spain
Defense date: 28 February, 2020, 09:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Hypoxia and Stem Cells in Normal and Tumor Development
Author: Camilla Niklasson
Main supervisor: Sofie Mohlin
Faculty opponent: Senior Professor Bengt Westermark, Uppsala University
Defense date: 21 November, 2019, 09:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Growth factor signaling in the breast tumor microenvironment
Author: Matteo Bocci
Main supervisor: Kristian Pietras
Faculty opponent: Professor Morag Park, Departments of Biochemistry, Medicine and Oncology, McGill University, Montreal, Canada
Defense date: 16 November, 2018, 09:30
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Exploring functional subsets of cancer-associated fibroblasts
Author: Michael Bartoschek
Main supervisor: Kristian Pietras
Faculty opponent: Professor Clare Isacke, The Institute of Cancer Research, London, UK
Defense date: 21 September, 2018, 09:30
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Translational studies on acute myeloid leukemia focus on the receptor tyrosine kinase FLT3
Author: Alissa Marhäll
Main supervisor: Kazi Uddin
Faculty opponent: Professor Edvard Smith, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden
Defense date: 6 April, 2018, 13:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Patient-derived xenografts as preclinical models of neuroblastoma
Author: Noémie Braekeveldt
Main supervisor: Daniel Bexell
Faculty opponent: Professor Jonas Nilsson, Sahlgrenska Cancer Center, University of Gothenburg
Defense date: 8 December, 2017, 09:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
HIF-dependent Signaling Pathways in Cancer
Author: Elinn Johansson
Main supervisor: Alexander Pietras
Faculty opponent: Professor Urban Lendahl, Department of Cell and Molecular Biology (CMB), Karolinska Institute, Stockholm, Sweden
Defense date: 15 September, 2017, 09:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Smac and Smac mimetics in breast cancer cell death
Author: Christian Holmgren
Main supervisor: Christer Larsson
Faculty opponent: Associate Professor Johan Lennartsson, Ludwig Institute for Cancer Research, Uppsala University
Defense date: 18 May, 2017, 09:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
TGF-β Family Signaling in Tumor Angiogenesis
Author: Nikolas Eleftheriou
Main supervisor: Kristian Pietras
Faculty opponent: Principal Investigator Mariona Graupera, Institut d'Investigació Biomèdica de Bellvitge, Spain
Defense date: 17 March, 2017, 13:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Collagen of the extracellular matrix. Functional and structural studies
Author: Per Olof Olsson
Main supervisor: Kristofer Rubin
Faculty opponent: Professor Stefan Johansson, Uppsala University
Defense date: 20 January, 2017, 13:00
Defense location: Segerfalksalen, BMC A10, Sölvegatan 17, Lund
Publisher: Division of Translational Cancer Research (TCR)
Exploring the functional heterogeneity of the tumor microenvironment
Author: Eliane Cortez
Main supervisor: Kristian Pietras
Faculty opponent: Professor Gerhard Christofori, Department of Biomedicine, University of Basel, Switzerland
Defense date: 12 May, 2016, 10:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
FLT3 and KIT in acute myeloid leukemia. Translational studies on oncogenic signaling from receptor tyrosine kinases. Translational studies on oncogenic signaling from receptor tyrosine kinases.
Author: Oscar Lindblad
Main supervisor: Lars Rönnstrand
Faculty opponent: Professor Bjørn Tore Gjertsen, University of Bergen, Norway
Defense date: 29 April, 2016, 13:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Studies on renal progenitor cells and kidney cancer
Author: Jennifer Hansson
Main supervisor: Martin Johansson
Faculty opponent: Professor Nigel Mongan, Faculty of Medicine & Health Sciences, The University of Nottingham, England
Defense date: 1 April, 2016, 09:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Transcriptional Regulation of HIF2A/EPAS1 in Neuroblastoma
Author: Arash Hamidian
Main supervisor: Sven Påhlman
Faculty opponent: Professor Frank Speleman, Center for Medical Genetics, Universiteit Ghent, Belgium
Defense date: 4 March, 2016, 09:15
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
The impact of Bcl-3 expression and signaling in cancer
Author: Karanukar Saamarthy
Main supervisor: Ramin Massoumi
Faculty opponent: Professor Aristidis Moustakas, Ludwig Institute for Cancer Research, Uppsala University
Defense date: 4 September, 2015, 13:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Tumor Suppressor function of the deubiquitinating enzyme BAP1 and its substrate gamma-tubulin in regulation of cell cycle and genome stability
Author: Reihaneh Zarrizi
Main supervisor: Ramin Massoumi
Faculty opponent: Professor Jeffrey Parvin, Biomedical Informatics, Ohio State University, USA
Defense date: 27 May, 2015, 09:00
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Erythropoietin receptor in growth control and anti-estrogen resistance of estrogen receptor positive breast cancer
Author: Susann Reinbothe
Main supervisor: Annika Jögi
Faculty opponent: Professor Aristidis Moustakas, Ludwig Institute for Cancer Research, Uppsala University
Defense date: 9 January, 2015, 09:15
Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund
Publisher: Division of Translational Cancer Research (TCR)
Regulation of cellular growth and identification of stromal gene signatures in breast cancer
Author: Sofia Winslow
Main supervisor: Christer Larsson
Faculty opponent: PhD Pierre Åhman, Sahlgrenska Cancer Center, Department of Pathology
Defense date: 15 May, 2014, 09:00
Defense location: Forum conference room, Ideon Agora, Scheelevägen 15, Lund
Publisher: Division of Translational Cancer Research (TCR)