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Doctoral theses

Doctoral theses derived from the Division of Translational Cancer Research (TCR). Click on the title for a direct link to the full electronic copy of the thesis.

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Cancer and Therapy: A look into stemness and the tumour microenvironment

Author: Carmen Rodriguez-Cupello

Main Supervisor: Kristian Pietras

Co-Supervisor: Anna Blom

Faculty Opponent: Professor Eric O'Neill, University of Oxford

Defense date: June 9th, 2022, 09:00

Defense location: Sharience, the Spark, Medicon Village

Publisher: Division of Translational Cancer Research (TCR)

Mechanisms of TRAIL- and Smac mimetic-induced cell death and phenotypical changes in breast cancer

Author: Victoria Granqvist

Main Supervisor: Christer Larsson

Co-Supervisor: Alexander Pietras

Faculty Opponent: Professor Bengt Hallberg, University of Gothenburg

Defense date: May 24th, 2022, 09:00

Defense location: Sharience, the Spark, Medicon Village

Publisher: Division of Translational Cancer Research (TCR)

Prostate cancer tissue biomarkers


Author: Felicia-Elena Marginean

Main Supervisor: Anders Bjartell

Co-Supervisor: Rebecka Hellsten and Agnieszka Krzyzanowska

Faculty Opponent: Associate professor Arno van Leenders, Rotterdam

Defense date: May 16th, 2022, 09:00

Defense location: Agardhsalen, CRC, Malmö

Publisher: Division of Translational Cancer Research (TCR)

The role of protein kinases in development and disease


Author: Renée Daams

Main Supervisor: Ramin Massoumi

Co-Supervisor: Karin Leandersson and Anette Gjörloff Wingren

Faculty Opponent: Professor Edvard Smith, Karolinska Institute

Defense date: March 24th, 2022, 09:00

Defense location: Sharience, Spark building at Medicon Village, and via Zoom

Publisher: Division of Translational Cancer Research (TCR)

Integrative studies of brain pericytes and their involvement in glioma and COVID-19


Author: Clara Oudenaarden

Main Supervisor: Kristian Pietras

Co-Supervisor: Göran B Jönsson

Faculty Opponent: Dr. Annika Keller, Division of Neurosurgery, University Hospital of Zürich

Defense date: February 11th, 2022, 09:00

Defense location: Sharience, Spark building at Medicon Village, and via Zoom

Publisher: Division of Translational Cancer Research (TCR)

The importance of Cyclophilins and Mps1 in cancer


Author: Sonia Simón Serrano

Main Supervisor: Ramin Massoumi

Co-Supervisor: Magnus J Hansson, Eskil Elmer and Daniel Bexell

Faculty Opponent: Prof. Peter R Galle, Universitätsmedizin der Johannes Gutenberg-Universität Main

Defense date: February 4th, 2022, 09:00

Defense location: GK-salen BMC and via Zoom

Publisher: Division of Translational Cancer Research (TCR)

Deregulation and editing of microRNAs in metastatic prostate cancer


Author: Gjendine Voss

Main Supervisor: Yvonne Ceder

Co-Supervisor: Håkan Axelson and Anders Bjartell

Faculty Opponent: Prof. Guido Jenster, Department of Urology, Erasmus University Medical Center, Rotterdam

Defense date: December 2nd, 2021, 09:00

Defense location: Stora Hörsalen, Medicon Village

Publisher: Division of Translational Cancer Research (TCR)

Stromal and tumor cell responses to hypoxia and treatment within the glioma microenvironment


Author: Vasiliki Pantazopoulou

Main Supervisor: Alexander Pietras

Co-Supervisor: Håkan Axelson

Faculty Opponent: Doc. Margareta Wilhelm, Karolinska Institute, Stockholm

Defense date: October 29th, 2021, 09:00

Defense location: Stora Hörsalen, Medicon Village

Publisher: Division of Translational Cancer Research (TCR)

Mechanisms of therapy resistance in acute lymphoblastic leukemia


Author: Kinjal Shah

Main Supervisor: Kazi Jhulash Uddin

Co-Supervisor: Lars Rönnstrand and Kristian Pietras

Faculty Opponent: Prof. Jean-Baptiste Demoulin, Université Catholique de Louvain, Brussels, Belgium

Defense date: October 28th, 2021, 09:15

Defense location: MV404, E24, via Zoom

Publisher: Division of Translational Cancer Research (TCR)

Role of FLT3 in Acute Myeloid Leukemia: Molecular mechanisms and Therapeutic opportunities


Author: Sausan Moharram

Main Supervisor: Lars Rönnstrand

Co-Supervisor: Kazi Jhulash Uddin and Björn Tore

Faculty Opponent: Prof. Atanasio Pandiella, University of Salamanca, Spain

Defense date: June 9th, 2021, 09:00

Defense location: MV404, E24, via Zoom

Publisher: Division of Translational Cancer Research (TCR)

Preclinical investigation of novel therapies against neuroblastoma


Author: Karin Hansson

Main supervisor: Daniel Bexell

Faculty opponent: Associate professor Fredrik Swartling, Uppsala

Defense date: 4 December, 2020, 09:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Harnessing urinary extracellular vesicles microRNA by acoustic trapping as potential biomarkers for prostate cancer


Author: Anson Ku

Main supervisor: Yvonne Ceder

Faculty opponent: Professor Juan Manuel Falcón Pérez, Derio Spain

Defense date: 28 February, 2020, 09:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Hypoxia and Stem Cells in Normal and Tumor Development


Author: Camilla Niklasson

Main supervisor: Sofie Mohlin

Faculty opponent: Senior Professor Bengt Westermark, Uppsala University

Defense date: 21 November, 2019, 09:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Growth factor signaling in the breast tumor microenvironment


Author: Matteo Bocci

Main supervisor: Kristian Pietras

Faculty opponent: Professor Morag Park, Departments of Biochemistry, Medicine and Oncology, McGill University, Montreal, Canada

Defense date: 16 November, 2018, 09:30

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Exploring functional subsets of cancer-associated fibroblasts


Author: Michael Bartoschek

Main supervisor: Kristian Pietras 

Faculty opponent: Professor Clare Isacke, The Institute of Cancer Research, London, UK

Defense date: 21 September, 2018, 09:30

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Translational studies on acute myeloid leukemia focus on the receptor tyrosine kinase FLT3


Author: Alissa Marhäll

Main supervisor: Kazi Uddin

Faculty opponent: Professor Edvard Smith, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden

Defense date: 6 April, 2018, 13:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Patient-derived xenografts as preclinical models of neuroblastoma


Author: Noémie Braekeveldt

Main supervisor: Daniel Bexell

Faculty opponent: Professor Jonas Nilsson, Sahlgrenska Cancer Center, University of Gothenburg

Defense date: 8 December, 2017, 09:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

HIF-dependent Signaling Pathways in Cancer


Author: Elinn Johansson

Main supervisor: Alexander Pietras

Faculty opponent: Professor Urban Lendahl, Department of Cell and Molecular Biology (CMB), Karolinska Institute, Stockholm, Sweden

Defense date: 15 September, 2017, 09:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Smac and Smac mimetics in breast cancer cell death


Author: Christian Holmgren

Main supervisor: Christer Larsson

Faculty opponent: Associate Professor Johan Lennartsson, Ludwig Institute for Cancer Research, Uppsala University

Defense date: 18 May, 2017, 09:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

TGF-β Family Signaling in Tumor Angiogenesis


Author: Nikolas Eleftheriou

Main supervisor: Kristian Pietras

Faculty opponent: Principal Investigator Mariona Graupera, Institut d'Investigació Biomèdica de Bellvitge, Spain

Defense date: 17 March, 2017, 13:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Collagen of the extracellular matrix. Functional and structural studies


Author: Per Olof Olsson

Main supervisor: Kristofer Rubin

Faculty opponent: Professor Stefan Johansson, Uppsala University

Defense date: 20 January, 2017, 13:00

Defense location: Segerfalksalen, BMC A10, Sölvegatan 17, Lund

Publisher: Division of Translational Cancer Research (TCR)

Exploring the functional heterogeneity of the tumor microenvironment


Author: Eliane Cortez

Main supervisor: Kristian Pietras

Faculty opponent: Professor Gerhard Christofori, Department of Biomedicine, University of Basel, Switzerland

Defense date: 12 May, 2016, 10:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

FLT3 and KIT in acute myeloid leukemia. Translational studies on oncogenic signaling from receptor tyrosine kinases. Translational studies on oncogenic signaling from receptor tyrosine kinases.


Author: Oscar Lindblad

Main supervisor: Lars Rönnstrand

Faculty opponent: Professor Bjørn Tore Gjertsen, University of Bergen, Norway

Defense date: 29 April, 2016, 13:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Studies on renal progenitor cells and kidney cancer


Author: Jennifer Hansson

Main supervisor: Martin Johansson

Faculty opponent: Professor Nigel Mongan, Faculty of Medicine & Health Sciences, The University of Nottingham, England

Defense date: 1 April, 2016, 09:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Transcriptional Regulation of HIF2A/EPAS1 in Neuroblastoma


Author: Arash Hamidian

Main supervisor: Sven Påhlman

Faculty opponent: Professor Frank Speleman, Center for Medical Genetics, Universiteit Ghent, Belgium

Defense date: 4 March, 2016, 09:15

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

The impact of Bcl-3 expression and signaling in cancer


Author: Karanukar Saamarthy

Main supervisor: Ramin Massoumi

Faculty opponent: Professor Aristidis Moustakas, Ludwig Institute for Cancer Research, Uppsala University

Defense date: 4 September, 2015, 13:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Tumor Suppressor function of the deubiquitinating enzyme BAP1 and its substrate gamma-tubulin in regulation of cell cycle and genome stability


Author: Reihaneh Zarrizi

Main supervisor: Ramin Massoumi

Faculty opponent: Professor Jeffrey Parvin, Biomedical Informatics, Ohio State University, USA

Defense date: 27 May, 2015, 09:00

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Erythropoietin receptor in growth control and anti-estrogen resistance of estrogen receptor positive breast cancer


Author: Susann Reinbothe

Main supervisor: Annika Jögi

Faculty opponent: Professor Aristidis Moustakas, Ludwig Institute for Cancer Research, Uppsala University

Defense date: 9 January, 2015, 09:15

Defense location: Hörsalen Medicon Village, Scheleevägen 2, Byggnad 302, Lund

Publisher: Division of Translational Cancer Research (TCR)

Regulation of cellular growth and identification of stromal gene signatures in breast cancer


Author: Sofia Winslow

Main supervisor: Christer Larsson

Faculty opponent: PhD Pierre Åhman, Sahlgrenska Cancer Center, Department of Pathology

Defense date: 15 May, 2014, 09:00

Defense location: Forum conference room, Ideon Agora, Scheelevägen 15, Lund

Publisher: Division of Translational Cancer Research (TCR)